Therafill

THERAFILL atelocollagen filler is a sterile and highly purified collagen filler,

which is dissolved in phosphate-buffered solution to enable soft-tissue

augmentation by intradermal injection.

TheraFill is biocollagen dermal filler manufactured by the Company's patented

technology.

It is CE approved, sterile device composed of highly purified atelocollagen

dispersed in phosphate-buffered physiological saline, and filled in 1ml syringe,

used for correction of wrinkles, nasolabial folds, scars and other soft tissue defects.

The porcine based atelocollagen is much safer and no risky for BSE, unlike other

collagen injections which is made from bovine protein. Because it is structurally

similar to human collagen, this product does not require skin testing.

Collagen is a fibrous extracellular protein forming connective tissue of dermis.

Collagen is inherently low in antigenicity and the most of its antigenicity are

assumed to result from the telopeptide regions.

TheraFill Atelocollagen Filler shows minimal antigen reaction because of the lack of

telopeptides by treatment with pepsin. It is made of porcine collagen (from piglets),

not bovine collagen.

Atelocollagen shows excellent properties for implantation in human body because

porcine collagen is structurally similar to human collagen.